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Exploring the Benefits of Local Plant Extracts as Effective and Safe Ingredients for Anti-Aging Cosm



Skin is the largest and most visible organ of the body. Many of its functions include temperature regulation, immunity from microorganisms, maintaining electrolyte balance, and protection from physical injuries, chemical agents and ultraviolet (UV) radiation. Aging occurs in every layer of the skin, primarily due to the degradation of its components. Induction of degradative enzymes and the abundant production of reactive oxygen species lead to skin aging.


Antiaging cosmetic products are popular management strategy to counter skin aging and the global market value of antiaging products has been projected to continue to grow sharply. However, the efficacy and safety of these products are questionable as there have been reports regarding the side effects of certain active ingredients. Skin irritation, photosensitivity, dermatitis, comedogenicity and carcinogenicity have all been recorded being the side effects of active compounds found in antiaging products.

As an alternative, bioactive compounds from nature can be explored as potential ingredients in antiaging cosmetics, through examining traditional claims and practices. Natural skin products have been in focus in recent years due to its hypoallergenic nature and significant impact in overcoming skin aging.


It would, therefore, be advantageous to provide a composition having substantial antiaging and antioxidant properties for eliminating, or at least alleviating, the side effects of conventional antiaging products such as skin irritation, photosensitivity, dermatitis, comedogenicity and carcinogenicity, the bioactive compounds of which are extracted from local plants. Although there are compositions for the same in the prior art, for many practical purposes, there is still considerable room for improvement.

The composition of the present invention comprises an effective amount of a eugenol compound extracted from Piper betle; an effective amount of an ellagic acid compound extracted from Areca catechu; an effective amount of a galangin compound extracted from Orthosiphon aristatus, Piper betle or combination thereof; and an effective amount of a quercetin compound extracted from Boesenbergia rotunda, Piper betle, Orthosiphon aristatus or combinations thereof, wherein the eugenol, the ellagic acid, the galangin and the quercetin in combination provide a synergistic increase in inhibition of collagenase, elastase and hyaluronidase, and in protection against free radicals in normal human skin fibroblast cells.


The method comprises topically applying a composition having antiaging and antioxidant properties to the skin, wherein the composition comprising an effective amount of a eugenol compound extracted from Piper betle; an effective amount of an ellagic acid compound extracted from Areca catechu; an effective amount of a galangin compound extracted from Orthosiphon aristatus, Piper betle or combination thereof; and an effective amount of a quercetin compound extracted from Boesenbergia rotunda, Piper betle, Orthosiphon aristatus or combinations thereof, wherein the eugenol, the ellagic acid, the galangin and the quercetin in combination provide a synergistic increase in inhibition of collagenase, elastase and hyaluronidase, and in protection against free radicals in normal human skin fibroblast cells.


 

Assoc. Prof. Dr. Nurshamimi Nor Rashid

nurshamimi@um.edu.my


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